Cingal® Injection – Ultrasound-Guided Knee Osteoarthritis Treatment

Chronic knee joint pain from osteoarthritis can drastically affect mobility, productivity, and overall well-being. For those seeking non-surgical solutions backed by clinical science, Cingal® stands out. Combining hyaluronic acid with a potent corticosteroid, Cingal® offers a single-injection solution that is fast-acting, long-lasting, and even more effective when ultrasound-guided for precision.

What is Cingal®?

Cingal® is an advanced viscosupplement injection used to manage knee osteoarthritis. It uniquely combines two active ingredients:

• Cross-linked hyaluronic acid (HA): A natural joint lubricant that restores the shock-absorbing quality of synovial fluid.

• Triamcinolone hexacetonide: A corticosteroid that rapidly reduces inflammation and pain.

Together, these components address both the root cause and the symptoms of osteoarthritis, helping patients regain joint function and comfort.

The Role of Synovial Fluid in Joint Health

Synovial fluid is essential for healthy joint movement. This viscous fluid, rich in hyaluronic acid, acts as a lubricant and cushion inside the joint, protecting cartilage from wear and tear.

In osteoarthritis:

• Hyaluronic acid levels decrease

• Synovial fluid becomes thin and ineffective

• Friction between bones increases

• Inflammation and cartilage breakdown accelerate

Cingal® replenishes the lost hyaluronic acid and directly combats inflammation, restoring the natural joint environment and reducing pain.

How Cingal® Works?

Cingal® works through a dual-action mechanism:

1. Hyaluronic Acid for Lubrication and Shock Absorption

The HA component mimics your joint’s natural lubricant, improving:

• Joint viscosity and elasticity

• Lubrication between cartilage surfaces

• Pain-free movement

2. Corticosteroid for Rapid Inflammation Control

The steroid acts quickly to:

• Reduce joint swelling

• Relieve pain within a few days

• Improve flexibility and function

This combination provides both immediate and long-term results, making Cingal® a superior option compared to HA or steroid alone.

Who is a Candidate for CINGAL®?

Cingal® is an excellent option for individuals seeking non-surgical relief from knee osteoarthritis. It is especially suitable for:

• Patients with mild to moderate knee osteoarthritis (Grade I–II)

• Those experiencing persistent knee pain, stiffness, or swelling

• Individuals who have not responded well to oral medications, physiotherapy, or standard HA injections

• People looking to delay or avoid knee replacement surgery

• Athletes or active individuals who require faster recovery and minimal downtime

• Patients who prefer a single-injection treatment with long-lasting effects

How is Cingal® Administered?

Cingal® is administered through an intra-articular injection—a minimally invasive procedure enhanced with ultrasound for optimal accuracy.

1. Pre-Injection Preparation

• The injection area is sterilized

• Local anesthesia may be applied for comfort

2. Ultrasound-Guided Injection

• The provider uses ultrasound to guide needle placement

• Cingal® is injected directly into the joint cavity

3. Post-Injection Instructions

• Light movement is encouraged

• Avoid high-impact activity for 24–48 hours

• Relief often begins within 3–7 days

Clinical Evidence Behind Cingal®

Numerous clinical trials support the use of Cingal®:

• Improved WOMAC scores for pain, stiffness, and function

• Greater pain relief than HA or steroid alone

• Relief lasting up to 6 months

• Enhanced efficacy with ultrasound-guided technique

Studies also confirm low risk of adverse events, making it a safe option for most patients.

Side Effects and Safety

Cingal® is generally well-tolerated. Minor, temporary effects may include:

• Mild swelling at the injection site

• Temporary joint soreness

• Rare allergic reaction

Ultrasound guidance significantly lowers the risk of misplacement or complications.

Conclusion:

Knee pain from osteoarthritis isn’t just a temporary discomfort—it can slowly take away your independence and quality of life. Cingal® offers a science-backed, minimally invasive solution that restores joint health with a single, ultrasound-guided injection.

If you're struggling with knee OA and looking for a non-surgical option that works fast and lasts, Cingal® may be your ideal solution.

References:

1. Altman, R. D., & Manjoo, A. (2021). Hyaluronic acid with corticosteroid for OA: Clinical outcomes and protocols. Current Rheumatology Reports, 23(2), 1-9.

2. Bannuru, R. R., Osani, M. C., & McAlindon, T. E. (2020). Ultrasound-guided intra-articular injections for OA: A meta-analysis. Osteoarthritis and Cartilage, 28(3), 289-301.

3. Conrozier, T., et al. (2020). Efficacy of Cingal® in knee OA compared to single-component treatments. Rheumatology International, 40(9), 1459–1465.

4. Pelletier, J. P., et al. (2021). Dual-action intra-articular treatments in osteoarthritis: Evidence and practice. Arthritis Research & Therapy, 23(1), 1-12.

5. Uth, K., & Trifonov, D. (2020). Viscosupplementation trends in OA management. Orthopedic Reviews, 12(2), 31–42.